Sodium dichloroacetate, commonly referred to simply as
dichloroacetate or DCA, is a buffered form of dichloracetic acid. This
synthetic chemical compound has gained attention because it shows some
potential as a cancer treatment. The buffered form of dichloracetic acid
is not an acid and can be taken by mouth without causing burning.
Sodium dichloroacetate is not an FDA-approved drug and so is not readily
available as a pharmaceutical-grade product. Consult with your doctor
if you are interested in this potential treatment, which is still in the
early research stages.
Uses
The only confirmed medical use for sodium dichloroacetate is
for removing warts and other skin growths, according to the American
Cancer Society. Researchers have tested it on humans for decreasing
lactic acid buildup, or lactic acidosis, in rare diseases involving
metabolism or caused by severe head injuries and malaria. Side effects
have been a problem with this possible treatment.
Theories/Speculation
Doctors at the University of Alberta have been researching
mitochondria in cancer cells, according to the ACS. Mitochondria are
tiny functional structures inside all cells. In the laboratory, abnormal
mitochondria appeared to keep cancer cells alive. Because sodium
dichloroacetate can affect an important enzyme in mitochondria, the
researchers theorized it might normalize mitochondria functioning in the
cancer cell, which might render it noncancerous.
Effects
A study by the University of Alberta researchers published
in the January 2007 issue of "Cancer Cell" showed that dichloroacetate
slowed the growth of cancer cells in a lab dish and that rats drinking
water treated with this substance experienced much slower tumor growth
than rats not drinking this type of water. The University of Alberta
website explains that dichloroacetate does not affect noncancerous
tissue, unlike most types of chemotherapy.
Specifics
The "Cancer Cell" study found that dichloroacetate kills
brain, breast and lung cancer cells. Further laboratory and animal
research noted by the ACS indicates sodium dichloroacetate effects on
specific types of cancer. Radiation seems more effective against
prostate cancer cells if they had already been exposed to
dichloroacetate. Breast cancer cells in rats did not spread as much if
the rats were given this substance, and mildly to moderately invasive
endometrial cancer cells were more prone to dying off when exposed to
dichloroacetate.
Safety
In the United States, only physicians involved in research
with sodium dichloroacetate can obtain it legally, because it is not an
approved medication or supplement. People may be able to participate in
clinical trials with the treatment, and some have obtained it online,
according to the ACS. The ACS warns that some suppliers sell only
industrial or technical-grade sodium dichloroacetate, which is not
manufactured with the same quality standards as the pharmaceutical-grade
form. Sodium dichloroacetate also is associated with numerous side
effects, including nerve damage resulting in weakness and numbness,
liver damage and low blood sugar. Additionally, some animal studies have
indicated that dichloroacetate causes liver cancer.
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