Saturday, March 19, 2016

Marijuana and Alzheimer's

                                    http://www.realfarmacy.com/cannabis-alzheimers/
                                    http://www.ncbi.nlm.nih.gov/pubmed/25024327
                              http://safeaccess.ca/research/RamirezCannabinoidsAlzhei.pdf
                              https://www.youtube.com/watch?v=_POQbhJUB10 
                             https://www.youtube.com/watch?v=Yd3zaoaN1eM
                                https://www.youtube.com/watch?v=7E49yrkOLsU
                          https://www.youtube.com/watch?v=T26dYtXO9l4

Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12384227

US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants (full - 2003) (Assignee (owner)- the US GOVERNMENT!) http://www.google.com/patents/US6630507

Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains (full – 2003) http://www.jneurosci.org/content/23/35/11136.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT

Safety and efficacy of Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia (abst - 2003) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=61

Open-label study of Dronabinol in the treatment of refractory agitation in Alzheimer’s disease : a pilot study (abst - 2003) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=92
Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells (full - 2004) http://www3.interscience.wiley.com/cgi-bin/fulltext/118757302/HTMLSTART

Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. (full – 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266095/?tool=pubmed

Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation (full - 2005) http://www.jneurosci.org/cgi/content/full/25/8/1904

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation (link to PDF– 2005) http://www.springerlink.com/content/tq777102q4185073/fulltext.html

Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3Kdependent mechanisms: role of NF-kappaB and p53. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/17017986

Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/15709490
Cannabinoid control of motor function at the basal ganglia. (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/16596785

Marijuana Ingredient May Stall Decline From Alzheimer's (news - 2005) http://www.sciencedaily.com/releases/2005/02/050224111638.htm

Research shows preventive effects of cannabinoids on Alzheimer’s disease (news – 2005) http://www.news-medical.net/news/2005/02/22/7901.aspx

Marijuana Slows Alzheimer's Decline (news - 2005) http://www.mapinc.org/drugnews/v05/n307/a10.html

Marijuana May Block Alzheimer's (news - 2005) http://news.bbc.co.uk/2/hi/health/4286435.stm

Marijuana Ingredient May Help Alzheimer's (news - 2005) http://www.webmd.com/alzheimers/news/20050223/marijuana-ingredient-may-help-alzheimers

Cannabinoids reduce the progression of Alzheimer's disease in animals (news - 2005) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=187#1
Pass the Doobie, pops (news - 2005) http://www.thefreelibrary.com/Pass+the+doobie%2c+pops.-a0131273013

The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/?tool=pmcentrez
A Molecular Link between the Active Component of Marijuana and Alzheimer’s Disease Pathology (full - 2006) http://www.ukcia.org/research/AlzheimersDiseasePathology.pdf

Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia (full/ forum repost - 2006) http://www.420magazine.com/forums/anxiolytic-effects/149595-delta-9-tetrahydrocannabinol-nighttime-agitation-severe-dementia.html

Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16732431

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NFkappaB involvement. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16490313
The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16389547

CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16837132

THC inhibits primary marker of Alzheimer's disease (news - 2006) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=225#3

Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease (news – 2006) http://www.scripps.edu/newsandviews/e_20060828/news.html

Marijuana's Active Ingredient May Slow Progression Of Alzheimer's Disease (news - 2006) http://www.sciencedaily.com/releases/2006/10/061009031544.htm

Marijuana may help stave off Alzheimer’s (news - 2006) http://www.msnbc.msn.com/id/15145917/
Marijuana May Slow Alzheimer's (news - 2006) http://www.webmd.com/alzheimers/news/20061006/marijuana-may-slow-alzheimers

Pot-Like Compound May Slow Alzheimer's (news - 2006) http://www.webmd.com/alzheimers/news/20061019/pot-like-compound-may-slow-alzheimers

Latest Buzz: Marijuana May Slow Progression Of Alzheimer's Disease (news - 2006) http://www.sciencedaily.com/releases/2006/10/061018151055.htm

Alzheimer's disease; taking the edge off with cannabinoids? (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17828287

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2189818&tool=pmcentrez

Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. (full - 2007) http://jpet.aspetjournals.org/content/322/3/1144.long

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1852513&tool=pmcentrez

The endocannabinoid system in targeting inflammatory neurodegenerative diseases (full - 2007) http://www.academia.edu/5172933/The_endocannabinoid_system_in_targeting_inflammatory_neurodegenerative_diseases
Comparison Analysis of Gene Expression Patterns between Sporadic Alzheimer's and Parkinson's Disease (abst – 2007) http://iospress.metapress.com/content/336t86725725564t/?p=00368d67a25c414b9e1ecc38b534bdfc&pi=10

Cannabinoid CB2 receptors in human brain inflammation (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219537/

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586121/?tool=pmcentrez

Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pmcentrez

Inflammation and aging: can endocannabinoids help? (full - 2008) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2408719&tool=pmcentrez

Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579926/?tool=pubmed

Role of CB2 receptors in neuroprotective effects of cannabinoids. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18291574

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18781980

Scientists are High on Idea that Cannabis Reduces Memory Impairment (news - 2008) http://www.physorg.com/news146320102.html

Israeli Research Shows Cannabidiol May Slow Alzheimer's Disease (news - 2008) http://www.israelnationalnews.com/News/News.aspx/125564

Marijuana may be good for the aging brain (news - 2008) http://www.news-medical.net/news/2008/11/19/43212.aspx

Alzheimer's sufferers may benefit from cannabis compound (news - 2008) http://www.news-medical.net/news/2008/03/11/36068.aspx

Marijuana reduces memory impairment (news - 2008) http://www.healthnewstrack.com/health-news-811.html

Cannabis 'could stop dementia in its tracks' (news - 2008) http://www.dailymail.co.uk/health/article-1087544/Cannabis-stop-dementia-tracks.html

LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's (news – 2008) http://www.eurekalert.org/pub_releases/2008-08/lsuh-lrr082008.php

Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain? (news - 2008) http://www.sciencedaily.com/releases/2008/11/081119120141.htm

Attacking Alzheimer's with Red Wine and Marijuana (news - 2008) http://www.alternet.org/story/110806/

Cannabis-derived medicines may help Alzheimer's (news - 2008) http://www.news-medical.net/news/2008/03/10/36024.aspx

Pot joins the fight against Alzheimer's, memory loss (news - 2008) http://www.scientificamerican.com/blog/60-second-science/post.cfm?id=pot-joins-the-fight-againstalzheim-2008-11-19

Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768535/?tool=pmcentrez

Cannabidiol: a promising drug for neurodegenerative disorders? (full - 2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2008.00065.x/full

The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19505450?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=18

Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons (abst – 2009) http://forum.grasscity.com/medical-marijuana-usage-applications/1029121-alzheimersstudy.html#post14325992
 Medical Marijuana and Alzheimer's Disease (news – 2009) https://www.marijuanadoctors.com/content/ailments/view/76?ailment=alzheimer-s-disease


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