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Rare but serious: a published case of toxic epidermal necrolysis after Moderna COVID-19 vaccination
A 2023 case report in Case Reports in Immunology describes a 30-year-old woman who developed toxic epidermal necrolysis (TEN) after a first dose of mRNA-1273 (Moderna).
The rash began around the injection site within two days, then spread. She developed targetoid lesions, blistering, skin sloughing over an estimated 30–40% of her body, plus mouth and eye involvement. She needed hospital and burn-unit care and was discharged on day 21.
The authors judged the vaccine a likely trigger because the eruption started at the shot site. Several of her other medicines have been linked to SJS/TEN in other reports, but she had been on them for months. She later tolerated PEG 3350 without a reaction, so they considered a major vaccine excipient less likely.
This is one case report, not proof of how often this happens. SJS/TEN after vaccination is rare. Case reports still matter for awareness: severe cutaneous reactions can occur, they can start at the injection site, and they need urgent specialist care.
If you or someone you know has a spreading blistering rash, mucosal sores, or peeling skin after any medicine or vaccine, that is an emergency—not something to wait out.
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