https://www.ncbi.nlm.nih.gov/pubmed/22536382
https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035421.g003
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335060/pdf/pone.0035421.pdf
https://www.ncbi.nlm.nih.gov/pubmed/31607599
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